Dr. Naseebullah Kakar
Professor Study Leave
Department of Biotechnology , Faculty of Life Sciences & Informatics

naseeb.kakar@buitms.edu.pk

Qualification

Postdoctoral (2024)
Human Genetics
UKSH Universitätsklinikum Schleswig-Holstein, Lübeck, Germany
Ph.D. (2016)
Molecular Medicine
Universität Ulm, Germany
Master's (2009)
Biotechnology and Informatics
BUITEMS, Pakistan

Teaching Courses

  • Human Genetics, Functional Genomics, Molecular Biology and Transcriptomics

Teaching Method

  • Collaborative Learning
  • Visual, Audio, & Kinesthetic Teaching
  • Inquiry-Based Learning

Research Interest

  • Human Genetics, Functional Genomics and Cancers with higher heritability

Membership

  • Member of the Alexander von Humboldt Society, Germany:
  • Member of the Undiagnosed Diseases Network International
  • Member of the American Society of Human Genetics
  • Member of European Society of Human Genetics

Awards & Achivements

  • ASHG’s Award, American Society of Human Genetics Annual Meeting in Washington, DC, USA
    2023
  • Alexander von Humboldt fellowship for the postdoc, Germany
    2021
  • PIFI CAS visiting Scientist award, CAS, 2019-20, China (not availed due to COVID-19).
    2019
  • Outstanding research award by the Higher Education Commission (HEC) Islamabad, Pakistan.
    2018
  • Selected paper presentation Award, GFH, Germany
    2015
  • Ph.D. position in the Institute for Human Genetics, University of Ulm, Ulm Germany
    2012
  • Best teacher award for 2009 by Higher Education Commission (HEC) Islamabad, Pakistan
    2010
Prof. Dr. Naseebullah Kakar (AvH fellow) is a Professor of Molecular Genetics and Biotechnology at the BUITEMS, where he began his career as a Research Associate in 2005 and steadily rose through academic ranks. He holds a Ph.D. in Molecular Medicine from IgradU Ulm, Germany, and has completed postdoc at the University UzL, Germany under the prestigious AvH fellowship as well as further training at the University UKR, Germany. His research expertise spans human molecular medicine and disease genomics. Dr. Kakar has published more than 40 research articles in leading international peer-reviewed journals, including Nat Genet and Genom Res with a collective IF of >200 and >1200 citations. He has successfully completed several national/international research projects. He has received multiple prestigious awards Nationally and Internationally.

Publications

Haplotype Phasing of Biallelic WNT10B Variants Using Long‐Read Sequencing in Split‐Hand/Foot Malformation Syndrome
Jelena Pozojevic, Naseebullah Kakar, Henrike L Sczakiel, Nathalie Kruse, Kristian Händler, Saranya Balachandran, Varun Sreenivasan, Martin A Mensah, Malte Spielmann (2025) Clinical Genetics vol. 107 no. 5 pp. 582-584
Further evidence of biallelic NAV3 variants associated with recessive neurodevelopmental disorder with dysmorphism, developmental delay, intellectual disability …
Naseebullah Kakar, Selinda Mascarenhas, Asmat Ali, Azmatullah, Syed M Ijlal Haider, Vaishnavi Ashok Badiger, Mobina Shadman Ghofrani, Nathalie Kruse, Sohana Nadeem Hashmi, Jelena Pozojevic, Saranya Balachandran, Mathias Toft, Sajid Malik, Kristian Händler, Ambrin Fatima, Zafar Iqbal, Anju Shukla, Malte Spielmann, Periyasamy Radhakrishnan (2025) Human Genetics vol. 144 no. 1 pp. 55-65
O1–1990 Clinical spectrum of dopamine transporter deficiency syndrome: from infantile parkinsonism-dystonia to juvenile parkinsonism
Vincenzo Leuzzi (2024) European Journal of Paediatric Neurology vol. - no. - pp. -
A GGC-repeat expansion in ZFHX3 encoding polyglycine causes spinocerebellar ataxia type 4 and impairs autophagy
Karla P Figueroa, Caspar Gross, Elena Buena-Atienza, Sharan Paul, Mandi Gandelman, Naseebullah Kakar, Marc Sturm, Nicolas Casadei, Jakob Admard, Joohyun Park, Christine Zühlke, Yorck Hellenbroich, Jelena Pozojevic, Saranya Balachandran, Kristian Händler, Simone Zittel, Dagmar Timmann, Friedrich Erdlenbruch, Laura Herrmann, Thomas Feindt, Martin Zenker, Thomas Klopstock, Claudia Dufke, Daniel R Scoles, Arnulf Koeppen, Malte Spielmann, Olaf Riess, Stephan Ossowski, Tobias B Haack, Stefan M Pulst (2024) Nature Genetics vol. 56 no. 6 pp. 1080-1089
LINE1-mediated epigenetic repression of androgen receptor transcription causes androgen insensitivity syndrome
Jelena Pozojevic, Radhika Sivaprasad, Joshua Lass, Franziska Haarich, Joanne Trinh, Naseebullah Kakar, Kristin Schulz, Kristian Haendler, Annemarie A Verrijn Stuart, Jacques C Giltay, Koen L van Gassen, Almuth Caliebe, Paul-Martin Holterhus, Malte Spielmann, Nadine C Hornig (2024) Scientific Reports vol. 14 no. 1 pp. 16302
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Work Experience

December 2021 to Date
Professor at Biotechnology
BUITEMS
January 2018 to December 2021
Associate Professor at Biotechnology and Informatics
BUITEMS
June 2016 to January 2018
Assistant Professor at Department of Biotechnology
BUITEMS
January 2012 to June 2016
Junior Researcher at Institute for Human Genetics
Ulm University
November 2009 to January 2012
Assistant Professor at Department of Biotechnology and Informatics
BUITEMS
November 2007 to November 2009
Lecturer at Department of Biotechnology and Informatics
BUITEMS
September 2005 to November 2007
Research Associate at Biotechnology and Informatics
BUITEMS

Projects

Next-generation Molecular Genetic Detection for the Chromosomal Abnormalities and Hematopoietic Malignancies in Balochistan Province
Balochistan Govt, National , Funded , 2021, Completed
This project aimed to establish and apply next-generation molecular diagnostic approaches for the de...
Mutational analysis of GDF5 followed by computational analysis and interaction of the mutant GDF5 with BMPR1B receptor
ORIC, BUITEMS, National , Funded , 2018, Completed
This project aimed to investigate the molecular and structural effects of mutations in the GDF5 (Gro...
Functional link between P63 and Zak using CRISPR/Cas9 in MEL cells lines
ORIC, BUITEMS, National , Funded , 2017, Completed
This project aimed to explore the functional relationship between the transcription factor P63 and t...
Molecular Genetic studies in syndromic and non-syndromic hereditary polydactyly
HEC, National , Funded , 2016, Completed
This research project focused on identifying and characterizing the genetic mutations responsible fo...
Strengthening and upgradation of the Molecular Biology laboratory for Genetic studies in mental retardation
HEC, National , Funded , 2010, Completed
This project aimed to enhance the research infrastructure and technical capacity of an existing Mole...

Certifications

Teaching Methodology
University of Nebraska Omaha, United States, 2019
Gene knockdown studies in Xenopus sp
Uni Ulm, Germany, 2015
In situ hybridization and CRISPR/cas9 in mice
Institute for Molecular Genetics Berlin, Germany, 2015
Training on Molecular Biology Techniques
UniKlinik Koln, Germany, 2011
Staff Development training by NAHI
HEC, Pakistan, 2005